Clinical Trials: SEARCH Intermediate Uveitis

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NCTID/Status
Study
Last Changed

1
NCT01092533
Recruiting
Myfortic for the Treatment of Non-infectious Intermediate Uveitis

Conditions: Non-infectious Intermediate Uveitis
Intervention: Myfortic, Decortin
March 24, 2010

2
NCT01314469
Completed
July 19, 2011

3
NCT00344253
Completed
Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis

Conditions: Uveitis, Intermediate; Macular Edema; Multiple Sclerosis
Intervention: Interferon Beta, Methotrexate
November 30, 2012

4
NCT01789320
Active, not recruiting
Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis

Conditions: Uveitis; Intermediate Uveitis; Posterior Uveitis; Panuveitis; Noninfectious Uveitis
Intervention: Triamcinolone Acetonide (Triesence®)
July 24, 2014

5
NCT01526889
Recruiting
Safety, Tolerability and Efficacy of Intravitreal LFG316 in Patients With Multifocal Choroiditis and Panuveitis (MCP)

Conditions: Multifocal Choroiditis; Panuveitis; Active Vitritis
Intervention: LFG316, Conventional Therapy
June 10, 2014

6
NCT00333814
Completed
A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis

Conditions: Intermediate Uveitis; Posterior Uveitis
Intervention: Dexamethasone, Dexamethasone, Sham Injection
March 11, 2011

7
NCT00570830
Completed
Retisert and Cataract Surgery in Patients With Severe Uveitis

Conditions: Intermediate Uveitis; Posterior Uveitis
Intervention: Retisert (fluocinolone Acetonide Implant)
August 29, 2014

8
NCT01032915
Terminated
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis

Conditions: Non-infectious Uveitis
Intervention: AIN457, AIN457, AIN457, Placebo
February 14, 2013

9
NCT00908466
Recruiting
Sirolimus as Therapeutic Approach to Uveitis

Conditions: Uveitis; Intermediate Uveitis; Posterior Uveitis; Panuveitis
Intervention: Sirolimus (rapamycin), Sirolimus (rapamycin)
May 25, 2010

10
NCT01280669
Not yet recruiting
Intravitreal Sirolimus as Therapeutic Approach to Uveitis

Conditions: Uveitis; Intermediate Uveitis; Posterior Uveitis; Panuveitis
Intervention: Intravitreal Injection 440mcg, Intravitreal Injection Of Sirolimus 880mcg
January 20, 2011

11
NCT01694186
Recruiting
Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert

Conditions: Posterior Uveitis; Intermediate Uveitis; Panuveitis
Intervention: FAI Insert, Sham Injection
September 2, 2014

12
NCT01095250
Terminated
Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis

Conditions: Uveitis
Intervention: AIN457, AIN457, AIN457, Placebo
May 2, 2012

13
NCT00132691
Completed
Multicenter Uveitis Steroid Treatment (MUST) Trial

Conditions: Uveitis
Intervention: Fluocinolone Acetonide Intraocular Implant, Oral Corticosteroid With Immunosuppressive Agents As Needed
June 22, 2012

14
NCT00001738
Completed
Vascular Endothelial Growth Factor (VEGF) in Uveitis

Conditions: Macular Edema, Cystoid; Uveitis
March 3, 2008

15
NCT00331331
Recruiting
The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease

Conditions: Uveitis; Vasculitis; Ocular Inflammatory Disease
March 14, 2014

16
NCT00615693
Completed
Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis

Conditions: Uveitis; Posterior Uveitis; Panuveitis
Intervention: AEB071
May 31, 2012

17
NCT01148225
Enrolling by invitation
July 21, 2014

18
NCT01905124
Not yet recruiting
Safety &Efficacy of CF101 to Subjects With Uveitis

Conditions: Uveitis, Posterior; Uveitis, Intermediate
Intervention: CF101, Placebo
July 30, 2014

19
NCT01124045
Completed
Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery

Conditions: Cataracts; Inflammation
Intervention: Difluprednate 0.05% Ophthalmic Emulsion, Prednisolone Acetate 1.0% Ophthalmic Suspension
April 30, 2013

20
NCT01090310
Terminated
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Study

Conditions: Non-infectious Uveitis
Intervention: AIN457, AIN457, AIN457, Placebo
July 25, 2013

21
NCT01684345
Recruiting
Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis

Conditions: Uveitis
Intervention: Placebo, Dose 1 Gevokizumab, Dose 2 Gevokizumab
July 10, 2014

22
NCT01327664
Withdrawn
December 5, 2013

23
NCT01747538
Recruiting
Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment

Conditions: Uveitis
Intervention: Placebo, Dose 1 Gevokizumab, Dose 2 Gevokizumab
July 10, 2014

24
NCT01103024
Terminated
Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis

Conditions: Uveitis
Intervention: AIN457, AIN457, AIN457, Placebo
May 2, 2012

25
NCT00499551
Withdrawn
A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis

Conditions: Uveitis
Intervention: Iontophoresis Second Generation Eyegate II Device
July 8, 2008

26
NCT01093846
Terminated
Safety and Efficacy of AIN457 in Behçet's Patients With Posterior or Panuveitis

Conditions: Uveitis
Intervention: AIN457, AIN457, Placebo
May 2, 2012

27
NCT01376362
Completed
Topical Interferon Gamma for Macular Edema Secondary to Uveitis

Conditions: Anterior Uveitis; Uveitis
Intervention: Interferon Gamma-1b
September 6, 2012

28
NCT00685399
Completed
Safety and Efficacy of AIN457 in Noninfectious Uveitis

Conditions: Active Uveitis That is Not From an Infection.
Intervention: AIN457 Subcutaneous Dose, AIN457 Low Dose (i.v), AIN457 High Dose (i.v)
November 18, 2013

29
NCT00943982
Completed
The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma

Conditions: Uveitis
Intervention: Interferon Gamma 1-b
June 25, 2010

30
NCT00995709
Completed
Phase III Study in Refractory Behcet's Disease

Conditions: Behcet Disease
Intervention: AIN457, AIN457, Placebo
May 2, 2012

31
NCT01109433
Recruiting
Immunogenetic Mechanisms in Behcet's Disease

Conditions: Behcet's Disease; Uveitis
March 14, 2014

32
NCT00539370
Completed
Human Samples and Data Repository

Conditions: Uveitis; Scleritis
June 13, 2012


34
NCT00001863
Completed
Leflunomide to Treat Uveitis

Conditions: Uveitis
Intervention: Leflunomide
March 3, 2008

35
NCT01950598
Enrolling by invitation
Frozen Versus Fresh Corneal Carriers for the Boston KPro Type I Donor Carriers

Conditions: Corneal Blindness; Boston Keratoprosthesis Type I Candidate
Intervention: Boston KPro Type I - Fresh Graft, Boston KPro Type I Surgery - Frozen Graft
September 22, 2013

36
NCT02049476
Recruiting
Study of the Effectiveness of Ozurdex for the Control of Uveitis

Conditions: Uveitis, Intermediate; Uveitis, Posterior
Intervention: Dexamethasone Pellet
January 28, 2014

37
NCT00404742
Completed
A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis

Conditions: Uveitis, Posterior; Uveitis, Intermediate; Panuveitis
Intervention: Placebo, LX211, LX211, LX211
June 21, 2012

38
NCT00404612
Completed
A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis

Conditions: Uveitis, Posterior; Uveitis, Intermediate; Panuveitis
Intervention: Placebo, LX211, LX211, LX211
October 9, 2012

39
NCT01314417
Terminated
Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate

Conditions: Non-infectious Intermediate and Posterior Uveitis
Intervention: Methotrexate
October 17, 2013

40
NCT01791192
Withdrawn
Study of FTY720 in Patients With Uveitis

Conditions: Acute Noninfectious Posterior, Intermediate, or Pan Uveitis
Intervention: FTY720, Oral Corticosteroid
April 15, 2014

41
NCT00326508
Completed
Combination Daclizumab/Denileukin Diftitox to Treat Uveitis

Conditions: Non-Infectious Intermediate and Posterior Uveitis
Intervention: Daclizumab
February 24, 2007

42
NCT01717170
Not yet recruiting
Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study

Conditions: Non-infectious Intermediate, Posterior, or Pan-uveitis.
Intervention: Tocilizumab
October 26, 2012

43
NCT01781936
Enrolling by invitation
Pilot Study of a Fluocinolone Acetonide Intravitreal Insert (FA-i) to Treat Intermediate-, Posterior-, or Panuveitis

Conditions: Uveitis Affecting the Posterior Segment.
Intervention: Fluocinolone Acetonide
May 28, 2014

44
NCT02125266
Recruiting
Safety and Preliminary Efficacy Study of V404 PDS in Uveitis

Conditions: Uveitis, Posterior; Uveitis, Intermediate
Intervention: V404
July 16, 2014

45
NCT00280826
Completed
Efalizumab to Treat Uveitis

Conditions: Uveitis; Macular Edema
Intervention: Efalizumab
January 28, 2011

46
NCT00001526
Completed
ANTI-TAC THERAPY FOR UVEITIS

Conditions: Uveitis
Intervention: Daclizumab (Zenapax)
September 7, 2007

47
NCT01243983
Completed
Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis

Conditions: Noninfectious Uveitis
Intervention: LX211
January 8, 2013

48
NCT01905579
Completed
Correlation Between Aqueous Protein Level and Clinical Grading of Flare and Flaremetry.

Conditions: Uveitis
Intervention: Paracentesis Of The Anterior Chamber
August 29, 2014

49
NCT00078689
Completed
Daclizumab and Sirolimus to Treat Uveitis

Conditions: Uveitis
Intervention: Daclizumab
July 19, 2008

50
NCT00406887
Completed
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis

Conditions: Anterior Uveitis; Panuveitis
Intervention: Difluprednate Ophthalmic Emulsion
November 29, 2006


1 2 Last


Last Updated

The last updated date is the most recent date when changes to a clinical trial were submitted to ClinicalTrials.gov. There is often a delay of a few days before the updated trial is available on the clinical trials website.

Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

First Received

The first received date is the date when the clinical trial was first submitted to ClinicalTrials.gov. There is often a delay of a few days before the trial is available on the clinical trials website.

Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.

Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

Safety Issue

If selected, restricts search results to those studies which have an outcome measure designated as a safety issue. Note that this is a poor estimate of the safety of a treatment or intervention, but it is all we have now.

Funded By

Studies are supported by one or more organizations called sponsors. Support includes contributions of facilities, expertise, and/or financial resources. All sponsors in the database have been assigned one of the following organization types:

National Institutes of Health (NIH)

Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.

Industry - the pharmaceutical companies

University/Organization - all others, including community-based organizations

Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.

Study Phase

Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions that study is seeking to answer:

In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.

In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.

In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.

These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.

Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.

Age Group

Studies may be designed for participants of particular ages:

Children (birth-17 yrs old)

Adults (18-65 yrs old)

Senior (66+ yrs old)

Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.

Gender

Searches can be restricted to studies which accept female or male participants.
Location Terms

If you are interested in a specific city (such as Los Angeles) or facility name (such as the Mayo Clinic), enter it as a location term. Not all studies include this level of detail, but if they do, this will find them.

Countries and States

Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state.

Study IDs

Each trial is assigned one or more identification numbers by the institute, agency, or organization sponsoring the trial. In addition, clinical trials assigns a unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit. Use this box to search for a trial by NCT identifier or any other study identification numbers.

Examples:

NCT00001789
97-h-0197
ia0006
actg 076

Sponsor (Lead)

Use this box to specify the name of an institute, organization, or company that is conducting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.

When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators

Use this box to specify institutes, organizations, or companies that are conducting or otherwise supporting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.

When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb

Outcome Measures

Outcome measures are used to evaluate trial results. For example, an obesity treatment might be evaluated by a measure of weight loss after 6 months. Measures can also be used to quantify side effects, such as number of myocardial infarctions, number of patients with heart arrhythmia, number of suicides, etc.

Use this box to specify an outcome measure used to evaluate trial results.

Examples:

weight loss
heart failure
suicide

Interventions

Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied. Interventions can also include less intrusive possibilities such as surveys, education, and interviews.

Use this box to specify drugs, devices, procedures, or vaccines used in a trial.

Examples:

clofibrate
cyclosporine
vitamin e

Conditions

Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov, conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.

Use this box to specify the conditions being studied.

Examples:

lupus
heart attack
leukemia
risk factors for breast cancer

Study Type

There are three types of studies available in ClinicalTrials.gov:

Interventional:

Studies where individuals are assigned to receive specific interventions. Participants may receive diagnostic, therapeutic or other types of interventions. Assignment of the intervention may or may not be random. Individuals are tracked and biomedical and/or health outcomes are assessed.

Observational:

Studies without an intervention. Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals. Participants may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the participants of the study.

Expanded Access:

Records describing the procedure for obtaining an experimental drug or device for patients who are failing on currently available treatments for their condition and also are unable to participate in ongoing clinical trials. Expanded Access records are used to register all types of non-protocol access to experimental treatments, including protocol exception, single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.

Study Results

Searches can be restricted to studies with or without results.

The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.

Recruitment Status

Also known as Enrollment Status.

Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.

If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.

Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.

Full list of all possible recruitment status values:

Open recruitment status values:

Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:

Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Search Terms

Use this box to specify general search terms found anywhere in the trial record.

Multiple terms can be separated by an AND (all uppercase).

Examples:

type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study


Help for Searching clinical trials

Help Topics:


Basic Search:

On the Basic Search page, enter a word or word(s) that you want to use to find studies. These may include diseases, interventions, and/or locations.

Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks

A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.


Advanced Search:

Many searches are a single term and can be performed with a few words in the search box. But, sometimes you need more control. Click on the Advanced Search tab (if starting a new search) or Refine Search tab (if modifying an existing search) to show additional search fields.

The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.

Search Terms:
Performs a general search in all sections of the study record, including title, description, conditions, interventions, locations, etc. Terms in this field are searched the same as Basic Search.

Recruitment:
Limits search results to studies that are open or closed. New volunteers may be able to participate in open studies, but not closed studies.

Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Study Results:
Limits search results based on whether the study has results or not:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov. Only a few studies have results available.

Study Type:
Limits search results to any of the following study types:
Interventional,
Observational, or
Expanded Access

Conditions:
Performs a search on fields describing the diseases or conditions being studied.

Interventions:
Performs a search on fields listing the drugs or interventions being studied.

Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.

Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.

When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Sponsor (Lead):
Performs a search on the sponsor field of a study.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.

When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Study IDs:
Performs a search on fields listing ID numbers.

Country/State:
Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state (e.g., United States, Alabama).

Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic). Not all studies include this level of detail, but if they do, this will find them.

Gender:
Limits search results to those studies that accept female or male participants.

Age Group:
Limits search results to those studies that include at least one of the specified age ranges. More than one age group can be selected.

Phase:
Limits search results to studies that are labeled with at least one of the specified phases. More than one Phase can be selected.

Funded By:
Limits search results to studies that have at least one sponsor of the specified types. More than one sponsor type can be selected.

Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.

First Received:
Limits search results to studies that were received by clinical trials within a specified date range. The "From" or "To" field can be left blank.

Last Updated:
Limits search results to studies that were modified within a specified date range. The "From" or "To" field can be left blank.


Refine Search:

Searches display a list of studies found (List Results tab). If you are not content with the search results, click on the Refine Search tab at the top of the list to modify your search.

Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.

For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California

When you are done making changes, click Search to display the new results.


Search Expressions:

Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California

Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack

Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS

Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )

Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.

To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.



© 2014 ICH GCP